Search and filter the primary research behind Halo's longevity model — what the evidence shows, how strong it is, and where its limits are — with a link to every original study.
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Strong evidence
Moderate evidence
Limited evidence
Evidence quality is graded per record, not for the library as a whole. Each card names the specific reliability or bias concerns that apply — self-report accuracy, reverse causation, confounding — next to the claim they qualify.
These summarise population-level associations. They describe patterns across large groups of people, not a prediction about you specifically.
National life expectancy at birth varies by roughly a decade across upper-middle vs high-income countries (WHO 2023 estimates); healthcare access and quality are the primary drivers of that gap
Causal status: Ecological/population-level association only — no study directly measures individual mortality risk for people who relocate for retirement
Reliability / bias notes: Expatriates and financially-resourced retirees often access better care than local population averages suggest, so this factor is treated as a small, precautionary adjustment rather than a well-evidenced individual risk factor
Low skeletal muscle mass index associated with 57% higher all-cause mortality risk (pooled RR 1.57, 95% CI 1.25–1.96) across 16 prospective studies, 81,358 participants
LDL-C ≥160 mg/dL associated with higher all-cause mortality (RR 1.34, 95% CI 1.00–1.80) and CVD death (RR 1.79, 95% CI 1.26–2.54) vs LDL-C 70–129 mg/dL, in a meta-analysis of 1,232,694 adults
Causal status: Causal support strong for CVD via Mendelian randomization and RCTs; all-cause mortality signal weaker/borderline
Reliability / bias notes: All-cause mortality CI crosses 1.0; relationship appears non-linear/U-shaped, complicated by reverse causation in low-LDL groups (illness-driven cholesterol decline)
Any resistance training vs none associated with 15% lower all-cause mortality (RR 0.85, 95% CI 0.77–0.93); dose-response peaked at ~60 min/week (27% reduction)
Causal status: Observational; supported by RCT evidence on intermediate outcomes
Reliability / bias notes: Only 10 cohort studies pooled; self-reported exposure; nonlinear dose-response not fully resolved
Shailendra et al · Am J Prev Med · 2022 · PMID 35599175