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Interventional / RCT evidence

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2 results

Blood pressure lowering for prevention of cardiovascular disease and death: systematic review and meta-analysis

Strongest tier
Blood PressureInterventional / RCT evidenceMeta-analysisSystematic review
Systematic review & meta-analysis
~10 mmHg SBP lowering in RCT meta-analysis reduced all-cause mortality RR 0.87; observational 20 mmHg higher usual SBP materially increased vascular mortality
Causal status: Strong randomized/interventional evidence
Reliability / bias notes: Treatment status, age, white-coat effect, overtreatment; lower is not always better
Ettehad et al · Lancet · 2016 · PMID 26724178
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Do seat belts and air bags reduce mortality and injury severity after car accidents?

Strong for injury mortality
Seat belt useInterventional / RCT evidence
Observational study
Front-seat seat-belt use reduces fatal/nonfatal injury risk by ~60%; trauma database mortality OR ~0.49 vs no restraint
Causal status: Strong causal/interventional evidence for crash injury prevention
Reliability / bias notes: Crash-conditioned evidence; risk-taking behaviours correlated with non-use
Cummins et al. · 2011 · PMID 21720604
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