Factor · Family History

Hereditary Cardiovascular disease

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Family history of premature death and risk of early onset cardiovascular disease

Strong for susceptibility
Hereditary Cardiovascular diseaseObservational evidence
Observational study
Danish cohort: premature family CVD death IRR ~1.72 for any CVD, ~2.21 for IHD; multiple affected relatives much higher
Causal status: Association/genetic + shared environment
Reliability / bias notes: Family-history accuracy; incomplete pedigree; mixed genetic and shared behavioural pathways
Ranthe et al · JACC · 2012 · PMID 22917005
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