Key finding
Danish cohort: premature family CVD death IRR ~1.72 for any CVD, ~2.21 for IHD; multiple affected relatives much higher
Evidence & causal status
Strong for susceptibility
Association/genetic + shared environment
Caveats & limitations
Reliability / bias notes: Family-history accuracy; incomplete pedigree; mixed genetic and shared behavioural pathways
This describes a population-level association from published research. It is not a prediction about any one individual, and association is not the same as causation unless stated otherwise above.