Reduced heart rate variability and mortality risk in an elderly cohort. The Framingham Heart Study

Tsuji et al · Circulation · 1994

Key finding

1-SD decrement in low-frequency HRV power associated with 1.70x greater all-cause mortality hazard (95% CI 1.37–2.09) over 4 years in an elderly community cohort

Evidence & causal status

Moderate

Associational; reflects autonomic dysfunction, prognostic value shown independent of traditional risk factors

Caveats & limitations

Reliability / bias notes: Older, smaller cohort (n=736, 74 deaths); short 2-hour ECG recording window; results in elderly may not generalize to younger adults

This describes a population-level association from published research. It is not a prediction about any one individual, and association is not the same as causation unless stated otherwise above.