Leisure time physical activity and mortality: detailed pooled dose-response relationship

Arem et al · JAMA Intern Med · 2015

Key finding

Highest vs lowest activity roughly 25–35% lower mortality in major prospective meta-analyses

Evidence & causal status

Strong

Mostly association; causal support substantial but mortality RCT evidence limited

Caveats & limitations

Reliability / bias notes: Reverse causation; questionnaire error; healthy-user bias

This describes a population-level association from published research. It is not a prediction about any one individual, and association is not the same as causation unless stated otherwise above.