Highest vs lowest Omega-3 Index quintile associated with 34% lower risk of death from any cause in the Framingham Offspring Cohort (n=2500, median 7.3-year follow-up)
Causal status: Associational; biologically plausible anti-inflammatory/anti-arrhythmic mechanism, but single cohort, not RCT-confirmed for mortality
Reliability / bias notes: Relatively short follow-up and single baseline measurement; modest sample size and event count (350 deaths)
Harris et al · J Clin Lipidol · 2018 · PMID 29559306