Factor · Family History

Hereditary Cancer

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Quantitative risk of positive family history in developing colorectal cancer: A meta-analysis

Moderate
Hereditary CancerMeta-analysisObservational evidence
Meta-analysis
First-degree relative with colorectal cancer associated with 1.87x risk of colorectal cancer (95% CI 1.68–2.09) in a pooled analysis of 46 studies
Causal status: Associational; shared genetics and environment both contribute
Reliability / bias notes: Colorectal-cancer-specific, not all cancer sites; this pooled estimate does not stratify by the relative's age at diagnosis (the under-60 cutoff used in our question could not be verified against a single landmark source)
Mehraban Far et al · World J Gastroenterol · 2019 · PMID 31435179
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