Key finding
Highest vs lowest GGT quartile associated with 56% higher all-cause mortality (pooled RR 1.56, 95% CI 1.34–1.83) across 7 prospective cohorts, 273,141 participants
Evidence & causal status
Moderate
Associational; proposed independent of alcohol intake but mechanism as a general oxidative-stress/liver marker not fully causal
Caveats & limitations
Reliability / bias notes: GGT is nonspecific (affected by alcohol, medications, fatty liver); Asian subgroup result not significant
This describes a population-level association from published research. It is not a prediction about any one individual, and association is not the same as causation unless stated otherwise above.